Doctor of Medical Sciences
Department of Outpatient Cardiology
H-index: RSCI 19, Scopus 18, Web of Science 18
Work Experience
In 1998–2005, Dr. Anfinogenova worked as an Assistant Professor and, later, an Associated Professor at the Department of Biophysics and Functional Diagnostics at Siberian State Medical University. From 2005 to 2011, she worked as a Postdoc in research centers in the USA and Canada including the Center for Cardiovascular Sciences of the Albany Medical Center (Albany, NY, USA) and the University of Calgary (Alberta, Canada) where she studied the mechanisms of systemic and cerebral blood flow regulation using advanced technologies such as the patch clamp electrophysiology, molecular biology, etc. In 2011–2015, Dr. Anfinogenova worked as a Leading Specialist in International Relations at Cardiology Research Institute of Tomsk NRMC. Since 2015, she has been working as a Leading Research Scientist in the Outpatient Cardiology Department at Cardiology Research Institute of Tomsk NRMC.
Education and Advanced Training
2022: Professional Retraining Diploma in “Public Administration in Foreign Policy” (The Diplomatic Academy of the Ministry of Foreign Affairs of Russia, Moscow, Russian Federation).
2014–2015: Professional Retraining Diploma in “Project Management in Science and Education” (Nation Research Tomsk Polytechnic University, Tomsk, Russian Federation).
2000 – 2005: Doctor of Medical Sciences Diploma in Biophysics and Physiology. Thesis: “The role of cell volume-sensitive ion transport-associated mechanisms in the regulation of vascular smooth muscle cell contractile function” (Siberian State Medical University, Tomsk, Russian Federation).
1994 – 1998: Candidate of Medical Sciences Diploma. Thesis: “Epithelium-dependent contractile responses of airway smooth muscles” (Siberian State Medical University, Tomsk, Russian Federation).
1993 – 1994: Graduate Student. Thesis: “Intracellular signaling mechanisms in the NO-induced relaxation of airway smooth muscles” (Siberian State Medical University, Tomsk, Russian Federation).
Research Interests
Cardiology, Clinical Pharmacology, Pharmacogenetics, Biophysics, Electrophysiology, Intracellular Signaling Systems, Ion Transport, Molecular Biology, Telemedicine, Nanotechnology, and Epidemiology.
Teaching
Biophysics, Physiology, and Telemedicine.
Awards
• 2024: Recipient of the Silver Prize “Noli Nocere!” in a framework of the II Russian Congress “Pharmacotherapy Safety 360°: Noli Nocere!” (Moscow, May 23-24 2024) for the best work titled “Prescribed Versus Taken Polypharmacy and Drug-Drug Interactions in Older Cardiovascular Patients during the COVID-19 Pandemic: Observational Cross-Sectional Analytical Study”, published by a team of authors in the Journal of Clinical Medicine (Q1) in 2023.
• 2021: Certificate of Merit from the Ministry of Science and Higher Education of the Russian Federation for significant achievements in the fields of science, technology, innovation, and nanotechnology and longstanding dedicated work.
• 2020: Appreciation Letter from the Duma of the city of Tomsk for dedicated work in the fields of science and medical services for the population of municipal settlement of the city of Tomsk on the 40th anniversary of Cardiology Research Institute.
• 2015: Certificate of Appreciation from the University Presidents Council of Tomsk Region.
• 2000: Award of Tomsk Region Administration for Young Scientists.
Grants
• 2022 – 2024: Principal Investigator for the research project supported by the Russian Science Foundation (#22-15-00313) titled “Emerging risk factors in the time of COVID-19 pandemic: New challenges to population on its way to active longevity”.
• 2012: Education Grant for attending the Executive Summer School “Technological Entrepreneurship and Management of Innovative Business Projects”. Joint Initiative by Intel, Open University Skolkovo, Skolkovo Biomedical Technology Cluster, innovationStudio, and Moscow State University (Areal Congress Hotel, Novaya Kupavna, Moscow, Russia).
• 2008: Travel & Accommodation Grant from Alberta Heritage for Medical Research (February 27 – March 02, 2008. Calgary, Alberta, Canada).
• 2004: Travel Grant for Young European Investigators for participation in the 14th European Meeting on Hypertension (June 13–17, 2004. Paris, France).
• 2003: Travel Grant for Young European Investigators for participation in the 13th European Meeting on Hypertension (June 13–17, 2003. Milan, Italy).
• 2001–2002: INTAS Fellowship (YSF2001/2-0168).
• 2001: Accommodation Grant for Young European Investigators for participation in the 11th European Meeting on Hypertension (June 15–19, 2001. Milan, Italy).
Articles
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Kamenshchikov N.O., Podoksenov Yu.K., Anfinogenova Y.J., Kozlov B.N., Svirko Yu.S., Pekarskiy S.E., Evtushenko V.V., Lugovsky V.A., Shipulin V.M., Lomivorotov V.V. Nitric oxide delivery during cardiopulmonary bypass reduces acute kidney injury: A randomized trial. The Journal of Thoracic and Cardiovascular Surgery 2022;163(4):1 393-1 403.
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Anfinogenova N.D., Trubacheva I.A., Popov S.V., Efimova E.V., Ussov W.Y. Trends and concerns of potentially inappropriate medication use in patients with cardiovascular diseases. Expert Opinion on Drug Safety 2021;20(10):1 191-1 206.
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Anfinogenova N.D., Vasiltseva O.Y., Vrublevsky A.V., Vorozhtsova I.N., Popov S.V., Smorgon A.V., Mochula O.V., Ussov W.Y. Right atrial thrombosis and pulmonary embolism: a narrative review. Seminars in Thrombosis and Hemostasis 2020;46(8):895-907.
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Anfinogenova N.D., Quinn M.T., Schepetkin I.A., Atochin D.N. Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation. Cells 2020;9(11):1-25.
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Plotnikov M.B., Chernysheva G.A., Smolyakova V.I., Aliev O.I., Trofimova E.S., Sherstoboev E.Y., Osipenko A.N., Khlebnikov A.I., Anfinogenova Ya.J., Schepetkin I.A., Atochin D.N. Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia. Cells 2020;9(8):1-12.
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Plotnikov M.B., Aliev O.I., Shamanaev A.Y., Sidekhmenova A.V., Anishchenko A.M., Fomina T.I., Rydchenko V.S., Khlebnikov A.I., Anfinogenova Y.J., Schepetkin I.A., Atochin D.N. Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats. Hypertension Research 2020;43:1 068-1 078.
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Zavadovsky K.V., Ilyushenkova J.N., Vasiltseva O.Y., Shipulin V.V., Anfinogenova Y.J., Bogdanov Y.I., Boshchenko A.A. Intralobar sequestration associated with the coronary-pulmonary artery fistula from the system of the circumflex artery. Circulation: Cardiovascular Imaging 2020;13(9):1-5.
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Ilyushenkova J., Sazonova S., Zavadovsky K., Batalov R., Rogovskaya Y., Anfinogenova Y., Lishmanov Y. Diagnostic efficacy of cardiac scintigraphy with 99mTc-Pyrophosphate for latent myocardial inflammation in patients with fibrillation. Cardiology Research and Practice 2020;2020:1-11.
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Plotnikov M.B., Chernysheva G.A., Aliev O.I., Smol'iakova V.I., Fomina T.I., Osipenko A.N., Rydchenko V.S., Anfinogenova Y.J., Khlebnikov A.I., Schepetkin I.A., Atochin D.N. Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats. Molecules 2019;24(9):1-23.
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Kamenshchikov N.O., Mandel I.A., Podoksenov Yu.K., Svirko Yu.S., Lomivorotov V.V., Mikheev S.L., Kozlov B.N., Shipulin V.M., Nenakhova A.A., Anfinogenova Ya.J. Nitric oxide provides myocardial protection when added to the cardiopulmonary bypass circuit during cardiac surgery: Randomized trial. The Journal of Thoracic and Cardiovascular Surgery 2019;157(6):2 328-2 336.
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Anfinogenova Y., Grakova E.V., Shvedova M., Kopieva K.V., Teplyakov A.T., Popov S.V. Interdisciplinary approach to compensation of hypoglycemia in diabetic patients with chronic heart failure. Heart Failure Reviews 2018;23:481-497.
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Shvedova M., Anfinogenova Y., Atochina-Vasserman E.N., Schepetkin I.A., Atochin D.N. c-Jun N-terminal kinases (JNK) and their inhibitors in myocardial and cerebral ischemia / reperfusion injury. Frontiers in Pharmacology 2018;9:1-17.
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Shvedova M., Anfinogenova Y., Popov S.V., Atochin D.N. Connexins and nitric oxide Inside and outside mitochondria: significance for cardiac protection and adaptation. Frontiers in Physiology 2018;9:1-13.
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Shchepetkin I., Shvedova M., Anfinogenova Y., Litvak M., Atochin D. Novel targets for positron emission tomography (PET) radiopharmaceutical tracers for visualization of neuroinflammation.. Journal of Physics: Conference Series 2017;886(1):1-5.
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Anfinogenova Y., Shvedova M., Popov S.V. Nanoparticles as agents targeting cholesterol crystallization in atherosclerosis. Medical Hypotheses 2017;102:19-22.
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Plotnikov M.B., Aliev O.I., Shamanaev A.Y., Sidekhmenova A.V., Anfinogenova Y., Anishchenko A.M., Fomina T.I., Arkhipov A.M. Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development. Clinical and Experimental Hypertension 2017;39(6):570-578.
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Evtushenko A.V., Evtushenko V.V., Smyshlyaev K.A., Pavlyukova E.N., Vaizov V.K., Katkov V.A., Maximov A.I., Anfinogenova Y. The Transaortic 'Edge-to-Edge' Mitral Valve Plasty in Combined Treatment of Obstructive Cardiomyopathy. Cardiology 2016;134(2):254-255.
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Evtushenko V., Smyshlyaev K., Bykov A., Kistenev Yu., Pavlyukova E., Katkov V., Kurlov I., Anfinogenova Y., Evtushenko A. Digital Technologies in Providing Development of Algorithms Surgical Treatment of Supraventricular Arrhythmias. MATEC Web Conf. 2016;79:1-9.
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Atochin D.N., Chernysheva G.A., Smolyakova V.I., Osipenko A.N., Logvinov S.V., Zhdankina A.A., Sysolyatin S.V., Kryukov Y.A., Anfinogenova Y, Plotnikova T.M., Plotnikov M.B. Neuroprotective effects of p-tyrosol after the global cerebral ischemia in rats. Phytomedicine 2016;23(7):784-792.
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Plotnikov M.B., Aliev O.I., Nosarev A.V., Shamanaev A.Y., Sidekhmenova A.V., Anfinogenova Y., Anishchenko A.M., Pushkina E.V. Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline. Biorheology 2016;53(2):93-107.
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Anfinogenova Y. Vagus nerve stimulation: Invasive or noninvasive?. The Anatolian Journal of Cardiology 2016;16(10):811-812.
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Evtushenko A.V., Evtushenko V.V., Bykov A.N., Sergeev V.S., Syryamkin V.I., Kistenev Yu.V., Anfinogenova Y. Physical justification of an increase in the efficacy of radiofrequency systems for myocardial ablation (Conference Paper). Key Engineering Materials 2016;685:432-435.
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Afanasiev S.A., Pavliukova E.N., Kuzmichkina M.A., Rebrova T.Yu., Anfinogenova Y., Likhomanov K.S., Karpov R.S. Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction. Annals of Noninvasive Electrocardiology 2016;21(6):548-556.
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Ripp T.M., Mordovin V.F., Pekarskiy S.E., Ryabova T.R., Zlobina M.V., Baev A.E., Anfinogenova Y., Popov S.V. Predictors of renal denervation efficacy in the treatment of resistant hypertension. Current Hypertension Reports 2015;17(12):1-7.
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Suslova T.E., Sitozhevskii A.V., Ogurkova O.N., Kravchenko E.S., Kologrivova I.V., Anfinogenova Y., Karpov R.S. Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation. Frontiers in Physiology 2015;5:1-8.
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Evtushenko A.V., Evtushenko V.V., Bykov A.N., Sergeev V.S., Syryamkin V.I., Kistenev Yu.V., Anfinogenova Ya.D., Smyshlyaev K.A., Kurlov I.O. Irrigated and Non-irrigated Radiofrequency Ablation Systems and Ways of Non-irrigated RF Systems Development. AIP Conference Proceedings 2015;1688:1-5.
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Nosarev A.V., Smagliy L.V., Anfinogenova Y., Popov S.V., Kapilevich L.V. Exercise and NO production: relevance and implication in the cardiopulmonary system. Frontiers in Cell and Developmental Biology 2015;2(73):1-7.
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Dyakova E.Y., Kapilevich L.V., Shylko V.G., Popov S.V., Anfinogenova Y. Physical exercise associated with NO production: signaling pathways and significance in health and disease. Frontiers in Cell and Developmental Biology 2015;3(19):1-8.