Innovative Products

Development of approach to remote personal ECG monitoring/ECG express

The project aims at the development of an approach to remote personal ECG monitoring (abnormal ST segment and cardiac arrhythmias) in patients with coronary artery disease (CAD) with high risk of the development of acute myocardial infarction and sudden cardiac death.

The project will solve the problem of prompt ECG registration even in the extreme conditions without help of a specialist and with a capability of instant ECG transfer to specialized centers for quick diagnostics of abnormal blood supply to the myocardium, life-threatening cardiac arrhythmias, and organization of fast arrival of emergency ambulance.

The first trial amount of devices with implemented solutions of the module for registration of thoracic leads and no-touch electrodes, record storage on SD card, review of the records on computer, autonomic power supply, and software has been produced.

Electrocardiograph ECG-express is a compact and portable device for measuring electrocardiogram in patients with coronary artery disease, cardiac arrhythmias, and high risk of acute myocardial infarction and sudden cardiac death at any time without involving a physician.

Key advantages of the device are as follows:

• Prompt diagnosing in critical situations
• Feasibility of individual control
• Simplicity and high speed of the use
• Affordable price

Development of new-generation coronary stent

The project aims at the development and elaboration of the technology and infrastructure of producing Russian new-generation metallic stent with biodegradable polymer coating containing chemically modified carbon nanomaterial selectively interacting with strictly defined fractions of the lipid spectrum of bioorganic media including atherosclerotic formations on the vascular walls, destroying them, and making them accessible for further metabolizing.

The product will allow solving the following problems of currently available stents:

• restenosis of coronary arteries caused by the endothelial growth and atherosclerotic plaque in the area of placed coronary stents.
• reducing the risk of myocardial infarction onset and sudden cardiac death

Currently, the project is at the R&D stage. In 2015 and in the beginning of 2016, we had completed the work stages, which received finding from the Foundation for Assistance to Small Innovative Enterprises in Science and Technology and, as a result, initiated creation of new-generation stent.

The next stage of work was «The study of the effects of biodegradable material containing nanoparticles, used for vascular stent coating, on the morphofunctional state of biological tissues».

In 2018, under support of Skolkovo Foundation, we performed works on «Research tests to characterize local effects of the object — medical product, namely — samples of coronary stent with biodegradable coating with different concentrations of chemically modified nanomaterial». The results of the study allowed to elucidate the optimal concentration of nanomaterial present in the composition of the biodegradable coating (3%).

The next step of the works consists in the assessment of morphofunctional changes in the surrounding tissues of the experimental animals after the implantation of the samples of the vascular stent with 3%-content of carbon nanocomposites in the long-term postoperative period.