Doctor of Medical Sciences, Full Member of the Russian Academy of Sciences
H-index: RSCI 48, Scopus 14, Web of Science 15
Rostislav S. Karpov, M.D., Ph.D., Professor, Member of the Russian Academy of Sciences, Scientific Supervisor of Tomsk NRMC, Scientific Supervisor of Cardiology Research Institute, Head of the Internal Medicine Department at the Siberian State Medical University of the Ministry of Healthcare of the Russian Federation.
In 1960, Rostislav S. Karpov graduated with honors from the Faculty of General Medicine of Tomsk Medical Institute. Under supervision of Professor Dmitry D. Yablokov who was a Member of the Russian Academy of Medical Sciences, Rostislav S. Karpov worked his way from a resident physician to a head of the department (1979). He was an originator and the first dean of the Continuous Medical Education Faculty at the Tomsk Medical Institute. In 1966, he defended doctoral thesis titled “Comparative diagnostic value of some immunological and biochemical tests in identifying the rheumatic process activity in patients with valvular heart diseases” for an academic degree of Candidate of Medical Sciences. In 1974, he defended doctoral thesis titled “Clinical and immunological characteristics of recurrent rheumatism in adults” for an academic degree of Candidate of Medical Sciences. In 1980, Rostislav S. Karpov was assigned as a Deputy Director for Research of the Siberian Branch of the All-Union Cardiology Research Center of the the Academy of Medical Sciences of the USSR. From that time through all following years, he has held a position of a Head of the Department of Atherosclerosis and Chronic Ischemic Heart Disease. In 1978, he was awarded an academic rank of a Full Professor at the Internal Medicine Department. In 1980, he was elected as a Corresponding Member and, in 1982, as a Member of the Academy of Medical Sciences of the USSR (later on the Russian Academy of Medical Sciences and the Russian Academy of Sciences). From 1986 to June 30, 2015, he had been a Director of Cardiology Research Institute, a Chairman of the Presidium of the Tomsk Science Center. From July, 2016, Rostislav S. Karpov has been Scientific Supervisor of Cardiology Research Institute and the entire Tomsk NRMC.
Rostislav S. Karpov is author of over 900 scientific works including 415 national and international articles, 28 monographs, and 10 chapters in monographs (including two chapters in “Guidelines for Internal Diseases” addressing fundamental issues of clinical medicine). He holds 43 patents and certificates of inventions. Under supervision of Rostislav S. Karpov, 42 dissertations for a degree of Doctor of Sciences and 81 dissertations for a degree of Candidate of Sciences (equivalent of Ph.D.) have been defended.
Scientific works of the Full Member of the Russian Academy of Sciences Rostislav S. Karpov are focusing on the most complex challenges of modern medicine. Main areas of his research comprise rheumatology, cardiology, clinical pharmacology, and clinical epidemiology. In the field of rheumatology, he gave clinical-and-pathogenetic characteristics of the variants of the rheumatism course in adults. Based on this, the system of immunological and biochemical markers of rheumatic process activity was developed. Inter-clinical immunological laboratory was organized. As a result of this work, two books and two composite volumes titled “Questions in Rheumatology” and “Diagnostics and treatment of rheumatoid arthritis and related syndromes” were published.
Primary research interests of Rostislav S. Karpov comprise the development of the methods for prevention, early diagnostics, and treatment of ischemic heart disease and arterial hypertension. Great attention is given to the problem of comorbidity (combination of ischemic heart disease, arterial hypertension, metabolic syndrome, diabetes mellitus, and rheumatic arthritis) and the development and clinical implementation of cutting-edge ultrasound technologies in cardiology. Improvement of organizational forms of medical care in Siberia has been of high priority. Indeed, he initiated the first-beyond-Ural Cardiology Center, mobile system of delivering medical care for cardiac patients from the sparsely populated areas based on motorship “Cardiologist”, Branch of Cardiology Research Institute in Tyumen (Tyumen Cardiology Center), Center of Child's Heart, Siberian Federal Arrhythmology Center, and information-and-education project titled “Healthy Heart”.
In the field of Cardiology, primary attention is given to the problem of atherosclerosis and coronary artery disease, in particular, to immune pathology and instrumental diagnostics. Criteria of detection of latent forms of dyslipoproteinemia were elaborated. Approaches to early diagnostics of coronary artery disease were improved. The associations between Т174М polymorphism of angiotensin gene and parameters of lipid spectrum in patients with essential hypertension and coronary artery disease are found.
A significant part of scientific and organizational work of Rostislav S. Karpov belongs to the implementation of new technologies for diagnostics and treatment of cardiovascular diseases in Siberian region. Indeed, the network of arrhythmology centers, largely equipped with diagnostic and treatment devices developed together with TOO ‘Electropuls’, has been established. New approach to delivery of specialized medical help to residents of sparsely populated areas of Siberia was justified and implemented based on mobile (motorship, autobus, and rail bus) automated consulting-and-diagnostic complexes.
Rostislav S. Karpov is a Member of the European and International Societies of Cardiologists, Member of the Medical Division Office of the Russian Academy of Sciences, Honorary Member of the Bulgarian Society of Cardiology, and Chairman of the Cardiology Task Group of interdepartmental Senatus Academicus N 53 of the Russian Academy of Sciences. He is a member of the editorial boards of the journals including Annals of the Russian Academy of Medical Sciences, Kardiologiia, Clinical Pharmacology, The Siberian Scientific Medical Journal, Patologiya Krovoobrashcheniya i Kardiokhirurgiya (Circulation Pathology and Cardiac Surgery), Russian Heart Failure Journal, Arterial’naya Gipertenziya (Arterial Hypertension), Systemic Hypertensions, Kardiologiya i Serdechno-Sosudistaya Khirurgiya (Cardiology and Cardiovascular Surgery), Profilakticheskaya Meditsina (Preventive Medicine), Atherosclerosis, Ateroskleroz i Dislipidemii (the Journal of Atherosclerosis and Dyslipidemias (JAD)), Russian Journal of Cardiology, Terapevticheskij Arkhiv, CardioСоматика, Kardiologicheskij Vestnik, Problems of Clinical Medicine (Barnaul), Complex Issues of Cardiovascular Diseases, Annaly Aritmologii, Diseases of the Heart and Blood Vessels, Russian Heart Journal, Legkoe (the Lung), Atmosfera (the Atmosphere), and the Siberian Medical Journal (Editor-in-Chief).
Rostislav S. Karpov is a Chairman of the Siberian Medical Foundation n.a. Dmitry D. Yablokov, a Member of the Board of the Russian Cardiological Society, a Chairman of the Tomsk Region Science-and-Practice Society of Cardiologists and Gerontologists, a Member of the Coordination Council under the Head of Tomsk Region Administration, a Member of Working Group on the Development of Measures for Improvement of the System of Medical and Social Care for Cardiovascular Diseases in a framework of the Expert Committee on Healthcare, a Chairman of Specialized Council for a Defense of Doctoral Theses for Academic Degrees of Candidate and Doctor of Sciences, and a Member of the Council of University Rectors in Tomsk Region. During many years, Rostislav S. Karpov has been a Chief Cardiologist of the Ministry of Healthcare of the Russian Federation in Siberian Federal District.
Long-standing productive research, scientific, managerial, and academic activities of Rostislav S. Karpov is highly esteemed and recognized. He has been awarded the Order of the Red Banner of Labour (1981), the USSR State Prize in the field of science and technology (1982), the Golden Medal of the Economic Achievements Exhibition (1985), Order of the October Revolution (1987), the Lapel Badge for Excellence in Healthcare (1990), the Order of Honor (1996), the title of Honorary Citizen of the city of Tomsk (1997), the Medal for Services to National Healthcare (2001), the Lapel Badge for Services to the Tomsk Region (2004), the Nikolay Pirogov’s Order for the Outstanding Achievements in Medicine (2005), the Prize n.a. N. S. Korotkov (2005), the Commemorative Medal to “the Best People of Russia” (the highest public award in the Russian Federation) for outstanding contribution to the development of scientific potential of Russia (2005), the Degree IV Order of Merit for the Fatherland (2007), the State Prize of the Russian Federation in Science and Technology (2009), the Medal for Contribution to Progress of Cardiology in Siberia (2010), the Certificate of Merit from the Tomsk Region Administration (2012), and the Certificate of Merit from Mayor of the City of Tomsk (2015). Professor Karpov is a Laureate of the Demidov Prize (2015) and Honorary Citizen of the Tomsk Region (June 30, 2016).
In 2017, Rostislav S. Karpov was awarded the Gold Medal in the name of S.P. Botkin for the series of works titled “Fundamental, clinical, and population-based cardiology”. He received the Certificates of Merit from the Federal Agency for Scientific Organizations, Ministry of Health of the Russian Federation, Siberian Branch of the Russian Academy of Sciences, Siberian State Medical University, and the Regional Committee Presidium of the Trade Union of Russian Healthcare Workers. In 2017, he also received the Honorary Diploma and the Commemorative Medal from the Russian Society of Cardiology. Rostislav S. Karpov is a Laureate of the Tomsk Region in the area of Education, Science, Healthcare, and Culture (2018). In 2018, he received a title of Honorary Doctor of the Tomsk State University, which is given to “great educators, scientists, and workers of culture”.
Kercheva M., Ryabova T., Gusakova A., Suslova T.E., Ryabov V., Karpov R.S. Serum soluble ST2 and adverse left ventricular remodeling in patients with ST-segment elevation myocardial infarction. Clinical Medicine Insights: Cardiology 2019; :1-8.
Ryabov V., Gombozhapova A., Rogovskaya Yu., Kzhyshkowska J., Rebenkova M., Karpov R. Cardiac CD68-positive and stabilin-1-positive macrophages in wound healing following myocardial infarction: from experiment to clinic. Immunobiology 2018;223(4-5):413-421.
Gombozhapova A., Rogovskaya Y., Shurupov V., Rebenkova M., Kzhyshkowska J., Popov S.V., Karpov R.S., Ryabov V. Macrophage activation and polarization in post-infarction cardiac remodeling. Journal of Biomedical Science 2017; :1-11.
Ryabov V.V., Kirgizova M.A., Suslova T.E., Karas S.I., Markov V.A., Karpov R.S. Relationships of growth factors, proinflammatory cytokines, and anti-inflammatory cytokines with long-term clinical results of autologous bone marrow mononuclear cell transplantation in STEMI. PLoS ONE 2017;12(5):1-19.
Afanasiev S.A., Pavliukova E.N., Kuzmichkina M.A., Rebrova T.Yu., Anfinogenova Y., Likhomanov K.S., Karpov R.S. Nonpharmacological Correction of Hypersympatheticotonia in Patients with Chronic Coronary Insufficiency and Severe Left Ventricular Dysfunction. Annals of Noninvasive Electrocardiology 2016;21(6):548-556.
Rogovskaya Y., Botalov R., Ryabov V., Rebenkova M., Karpov R., Popov S., Kzhyshkowska J. Role of Inflammation, Viruses and Tissue Macrophages in The Development of Idiopathic Arrhythmia and Heart Failure. Key Engineering Materials 2016;683:487-492.
Ryabov V.V., Kruchinkina E.V., Rogovskaya Yu.V., Ryabova T.R., Batalov R.E., Rebenkova M.S., Popov S.V., Karpov R.S. Clinical and morphological characteristics of chronic inflammation in the myocardium in patients with decompensated chronic heart failure accompanied by ischemic systolic dysfunction: study protocol for an open-label nonrandomized trial. Clinical Trials in Degenerative Diseases 2016;1(4):160-165.
Suslova T.E., Sitozhevskii A.V., Ogurkova O.N., Kravchenko E.S., Kologrivova I.V., Anfinogenova Y., Karpov R.S. Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation. Frontiers in Physiology 2015;5:1-8.
# 9,789,134 Agent For Selective Adjustment Of Blood Lipids. Карпов Р.С.,Ахмедов Ш.Д.,Афанасьев С.А.,Филимонов В.Д.,Постников П.С.,Трусова М.Е. 2017-10-17