Department of Hypertension

Head

Mordovin V.F.

Doctor of Medical Sciences, Professor

H-index: RSCI 12, Scopus 7, Web of Science 5

mordovin@cardio-tomsk,ru

+7 (3822) 55 81 22

About the Department

The department was established in 1980. The team comprises seven research fellows and four physicians including three doctors of medical science, one professor, six candidates of medical science, and three high level certificate physicians. Employees of the department defended two dissertations for degree of doctor of medical sciences and 15 dissertations for degree of candidate of medical sciences. Over the last 15 years, 210 scientific works including six books and 35 articles in national and international journals were published; 10 patents of inventions of the Russian Federation were received.

Main areas of scientific research

The development of new high-tech methods for diagnostics and treatment of patients with arterial hypertension.

New medical technologies for detection of pathological changes in the brain, heart, and kidneys in patients with various forms of hypertension were developed based on MRI, ultrasound, and biochemical methods. New methods for increase of the efficacy of hypotensive therapy were proposed; new approaches to endovascular treatment in patients with resistant form of diseases were developed.

Specifics of the effects of beta-blockers, calcium antagonists, and angiotensin-2 blockers on the changes of cerebral hemodynamics were elucidated.

Significant differences between the characteristics of hypotensive effects of beta-blockers for treatment of hypertensive patients with coronary artery disease after coronary artery bypass surgery depending on the tone of autonomous nervous system were identified. New method for non-invasive assessment of functional integrity of radial artery as a conduit in coronary artery bypass was proposed and its prognostic significance was identified.

Utility model of the device allowing for dose use of oxygen and carbon dioxide inhalation aimed at the assessment of cerebral circulation autoregulation parameters was developed. The types of abnormalities in cerebral vascular reserve in hypertensive patients varying in degree of diseases and in changes of 24-h profiles of blood pressure were identified.

To increase the efficacy of transcatheter treatment of resistant hypertension, the original method of renal denervation with redistribution of the application to the distal part of the renal arterial trunk and segmental branches of the renal artery was developed, which significantly increased hypotensive and organoprotective effects of the intervention. New medical technologies for assessment of the results of drug therapy and catheter-based methods of treatment for hypertension are under development.

Practical activities

Annually, over 1000 patients with various forms of hypertension including patients with hypertension resistant to therapy with hypotensive drugs are examined in the department. The methods for 24-h monitoring of blood pressure and ECG as well as functional and stress testing with determination of the parameters of vascular reactivity are used. The complex of ultrasonic, MRI, scintigraphic, and biochemical methods of study are used.

State-of-the-art methods of antihypertensive drug treatment in hypertensive patients and high-tech endovascular interventions in patients with insufficient efficacy of hypotensive drugs are used. Each year, number of patients with hypertension and coronary atherosclerosis in whom myocardial revascularization is achieved through endovascular treatment and coronary artery bypass is growing.

Many years of clinical and scientific experience, high professionalism of employees, and the use of state-of-the-art methods of diagnostics and treatment ensure delivery of effective assistance to patients with various forms of hypertension including its severe forms.