Laboratory of Experimental Cardiology

Head

Maslov L.N.

Doctor of Medical Sciences, Professor

H-index: RSCI 27, Scopus 20, Web of Science 18

maslov@cardio-tomsk.ru

+7 (3822) 26 21 74

About the Laboratory

Laboratory of Experimental Cardiology was established in 1991. The team comprises 10 members including four doctors of sciences, one professor, and four candidates of sciences. Members of the laboratory defended 4 dissertations for degree of doctor of sciences and 15 dissertations for degree of candidate of sciences. 368 scientific articles indexed by Scopus and three books have been published. 13 patents of inventions of the Russian Federation were received.

Main areas of scientific research

The study of cardioprotective properties of opioids and cannabinoids. The study of receptor and signaling mechanisms of infarct-limiting and cytoprotective effects of adaptation to prolonged continuous normobaric hypoxia, its effects on bioenergy metabolism of the heart in the modeling of ischemia-reperfusion. The study of receptor and signaling mechanisms of infarct-limiting and stress-limiting effects of hypoxic preconditioning. The investigation of infarct-limiting effects of adaptation to cold was initiated. The studies on pathogenesis of stress-induced cardiomyopathy have been performed.

Data showed that the activation of peripheral opioid receptors increases the resistance of the heart to arrhythmogenic action of ischemia-reperfusion. The obtained results suggest that phyto-adaptogens exert anti-arrhythmic and cardioprotective effects. The activation of peripheral opioid receptors increases the resistance of the isolated perfused heart to harmful effects of ischemia-reperfusion. Data showed that the stimulation of cardiac cannabinoid receptors exerts anti-necrotic effect in the model of total ischemia-reperfusion of the isolated heart.

The study showed that the stimulation of peripheral µ2-, δ2-, and κ-opioid receptors as well as the activation of cannabinoid receptors prevent reperfusion injury of the heart i.e. imitate the phenomenon of postconditioning. The signaling mechanism of cardioprotective effects of cannabinoids and opioids was studied. The receptor and signaling nature of the infarct-limiting and anti-arrhythmic effects of adaptation to hypoxia and hypoxic preconditioning was studied. Data showed that anti-necrotic effect of postconditioning is the consequence of the activation of δ1-ОР.

The studies devoted to cardiovascular effects of cold adaptation have been initiated. Data showed that the activation of β1-adrenergic receptors plays the key role in the pathogenesis of stress-induced cardiomyopathy.

Members of the laboratory perform the studies aimed at creation of new drugs based on opioids and cannabinoids.

Laboratory of Experimental Cardiology closely collaborates with the researchers from the USA, Great Britain, Czech Republic, Israel, China, Belarus, and Ukraine as seen from joint articles and grants.