Department of Nuclear Medicine

Head

Zavadovskiy K.V.

Doctor of Medical Sciences

H-index: RSCI 15, Scopus 9, Web of Science 8

konstz@cardio-tomsk.ru

+7 (3822) 55 82 98

About the Department

Department of Nuclear Medicine was established in 1982.
The team comprises 21 member including four doctors of medical sciences, five candidates of medical sciences, and four high level certificate physicians. Members of the department published 1050 scientific works including 350 articles in the national and international journals, 10 books, and National Guidelines on Radionuclide Diagnostics; 15 patents of inventions of the Russian Federation were received.

Main areas of scientific research

The development and approbation of the radiopharmaceuticals, improvement of the available methods, and implementation of new methods of radiodiagnostic studies in nuclear medicine.

Together with Research Institute of Nuclear Physics at the Tomsk Polytechnic University, original radiopharmaceuticals «Thallium Chloride, 199Tl» for studying myocardial perfusion, «Thallium Diethyl-Dithiocarbamate, 199Tl» for perfusion scintigraphy of the brain, «Solution of Sodium Iodohippurate, 123I» for assessment of renal function, and «Solution of Sodium Pertechnetate, 99mTc, Extraction» for visualization of internal organs were developed and implemented in practical healthcare. Moreover, Thallium Chloride, 199Tl» for studying myocardial perfusion, «Thallium Diethyl-Dithiocarbamate, 199Tl» were produced and used for the first time in the world. Currently, the work is ongoing on creation of the number of new radiopharmaceutical, in particular, research and development of the indicator for the assessment of myocardial metabolism «Iodophen, 123I», marker of infectious inflammation «Ciprofloxacin, 99mTc», and a drug allowing to study the state of sympathetic activity of the heart, «MIBG, 123I».

The studies showed that abnormal functional state of the pulmonary circulation is the earliest sign of the development of heart failure. In the course of integrated multispiral computed angiography of the coronary arteries and single photon emission computed tomography of the myocardium in patients with coronary artery disease, a relationship between the severity of myocardial perfusion abnormalities and degree of stenosis of the coronary arteries was discovered. Data showed that the scintigraphy study of the heart with noradrenaline analogue 123I-MIBG and 123I-labeled lipid acid has a high significance for prognosis of treatment in patients with atrial fibrillation, ischemic cardiomyopathy, and dilated cardiomyopathy. It has been proved that radionuclide equilibrium tomoventriculography allows to determine localization of the focus of the ventricular extrasystoles as well as to evaluate its effects on contractility of the heart. We demonstrated an opportunity to use the method of dynamic renal scintigraphy for evaluation of the efficacy of nephroprotection in X-ray contrast-enhanced procedures as well as we obtained new evidence of cardioprotective and nephroprotective efficacies of hypoxic preconditioning or administration of myocardial stabilizer in coronary artery bypass grafting. The unique methods of marking the immune-competent cells of human blood specifically accumulating the inflammation foci were developed, verified, and implemented in practice. Currently, the technology of non-invasive assessment of the coronary flow reserve is under development in the laboratory.

Practical activities

Main area of practical activity is delivery of radionuclide and X-ray studies for the diagnostics of cardiovascular diseases and evaluation of the efficacy of administered treatment. In the laboratory, there is the only-in-Russia integrated single photon emission and X-ray computed tomography machine of expert class. To examine patients from Cardiology Research Institute and ambulatory patients, 18 methods of radionuclide studies and 11 methods of Multislice Helical CT studies including combined myocardial perfusion scintigraphy and non-invasive angiography of the coronary arteries are used. During the time of the department operation, over 230,000 radiodiagnostic studies has been performed.